diff --git a/webrtc/modules/audio_coding/BUILD.gn b/webrtc/modules/audio_coding/BUILD.gn
index 6e280da02..0832d6f4f 100644
--- a/webrtc/modules/audio_coding/BUILD.gn
+++ b/webrtc/modules/audio_coding/BUILD.gn
@@ -532,6 +532,10 @@ source_set("isacfix") {
     "../../system_wrappers",
   ]
 
+  if (cpu_arch == "arm64") {
+    deps += [ ":isac_neon" ]
+  }
+
   if (rtc_build_armv7_neon) {
     deps += [ ":isac_neon" ]
 
@@ -582,16 +586,39 @@ source_set("isacfix") {
   }
 }
 
-if (rtc_build_armv7_neon) {
+if (rtc_build_armv7_neon || cpu_arch == "arm64") {
   source_set("isac_neon") {
-    sources = [
-      "codecs/isac/fix/source/entropy_coding_neon.c",
-      "codecs/isac/fix/source/filterbanks_neon.S",
-      "codecs/isac/fix/source/filters_neon.S",
-      "codecs/isac/fix/source/lattice_neon.S",
-      "codecs/isac/fix/source/lpc_masking_model_neon.S",
-      "codecs/isac/fix/source/transform_neon.S",
-    ]
+    sources = [ "codecs/isac/fix/source/entropy_coding_neon.c" ]
+
+    if (rtc_build_armv7_neon) {
+      sources += [
+        "codecs/isac/fix/source/filterbanks_neon.S",
+        "codecs/isac/fix/source/filters_neon.S",
+        "codecs/isac/fix/source/lattice_neon.S",
+        "codecs/isac/fix/source/lpc_masking_model_neon.S",
+        "codecs/isac/fix/source/transform_neon.S",
+      ]
+
+      # Enable compilation for the ARM v7 Neon instruction set. This is needed
+      # since //build/config/arm.gni only enables Neon for iOS, not Android.
+      # This provides the same functionality as webrtc/build/arm_neon.gypi.
+      # TODO(kjellander): Investigate if this can be moved into webrtc.gni or
+      # //build/config/arm.gni instead, to reduce code duplication.
+      # Remove the -mfpu=vfpv3-d16 cflag.
+      configs -= [ "//build/config/compiler:compiler_arm_fpu" ]
+      cflags = [
+        "-mfpu=neon",
+      ]
+    }
+
+    if (cpu_arch == "arm64") {
+      sources += [
+        "codecs/isac/fix/source/filterbanks_neon.c",
+        "codecs/isac/fix/source/filters_neon.c",
+        "codecs/isac/fix/source/lattice_neon.c",
+        "codecs/isac/fix/source/transform_neon.c",
+      ]
+    }
 
     include_dirs = [
       "../../..",
@@ -605,17 +632,6 @@ if (rtc_build_armv7_neon) {
       ]
     }
 
-    # Enable compilation for the ARM v7 Neon instruction set. This is needed
-    # since //build/config/arm.gni only enables Neon for iOS, not Android.
-    # This provides the same functionality as webrtc/build/arm_neon.gypi.
-    # TODO(kjellander): Investigate if this can be moved into webrtc.gni or
-    # //build/config/arm.gni instead, to reduce code duplication.
-    # Remove the -mfpu=vfpv3-d16 cflag.
-    configs -= [ "//build/config/compiler:compiler_arm_fpu" ]
-    cflags = [
-      "-mfpu=neon",
-    ]
-
     configs += [ "../..:common_config" ]
     public_configs = [ "../..:common_inherited_config" ]
 
diff --git a/webrtc/modules/audio_coding/codecs/isac/fix/source/codec.h b/webrtc/modules/audio_coding/codecs/isac/fix/source/codec.h
index 488ee2e76..cf1266a62 100644
--- a/webrtc/modules/audio_coding/codecs/isac/fix/source/codec.h
+++ b/webrtc/modules/audio_coding/codecs/isac/fix/source/codec.h
@@ -90,7 +90,8 @@ void WebRtcIsacfix_Spec2TimeC(int16_t* inreQ7,
                               int32_t* outre1Q16,
                               int32_t* outre2Q16);
 
-#if (defined WEBRTC_DETECT_ARM_NEON) || (defined WEBRTC_ARCH_ARM_NEON)
+#if (defined WEBRTC_DETECT_ARM_NEON) || (defined WEBRTC_ARCH_ARM_NEON) || \
+  (defined WEBRTC_ARCH_ARM64_NEON)
 void WebRtcIsacfix_Time2SpecNeon(int16_t* inre1Q9,
                                  int16_t* inre2Q9,
                                  int16_t* outre,
@@ -174,7 +175,8 @@ void WebRtcIsacfix_FilterMaLoopC(int16_t input0,
                                  int32_t* ptr1,
                                  int32_t* ptr2);
 
-#if (defined WEBRTC_DETECT_ARM_NEON) || (defined WEBRTC_ARCH_ARM_NEON)
+#if (defined WEBRTC_DETECT_ARM_NEON) || (defined WEBRTC_ARCH_ARM_NEON) || \
+  (defined WEBRTC_ARCH_ARM64_NEON)
 int WebRtcIsacfix_AutocorrNeon(int32_t* __restrict r,
                                const int16_t* __restrict x,
                                int16_t N,
diff --git a/webrtc/modules/audio_coding/codecs/isac/fix/source/entropy_coding.h b/webrtc/modules/audio_coding/codecs/isac/fix/source/entropy_coding.h
index 741646f01..63fe61fc7 100644
--- a/webrtc/modules/audio_coding/codecs/isac/fix/source/entropy_coding.h
+++ b/webrtc/modules/audio_coding/codecs/isac/fix/source/entropy_coding.h
@@ -147,7 +147,8 @@ void WebRtcIsacfix_MatrixProduct2C(const int16_t matrix0[],
                                    const int matrix0_index_factor,
                                    const int matrix0_index_step);
 
-#if (defined WEBRTC_DETECT_ARM_NEON) || (defined WEBRTC_ARCH_ARM_NEON)
+#if (defined WEBRTC_DETECT_ARM_NEON) || (defined WEBRTC_ARCH_ARM_NEON) || \
+  (defined WEBRTC_ARCH_ARM64_NEON)
 void WebRtcIsacfix_MatrixProduct1Neon(const int16_t matrix0[],
                                       const int32_t matrix1[],
                                       int32_t matrix_product[],
diff --git a/webrtc/modules/audio_coding/codecs/isac/fix/source/filterbank_internal.h b/webrtc/modules/audio_coding/codecs/isac/fix/source/filterbank_internal.h
index 2aa587fc0..5f4c7be6f 100644
--- a/webrtc/modules/audio_coding/codecs/isac/fix/source/filterbank_internal.h
+++ b/webrtc/modules/audio_coding/codecs/isac/fix/source/filterbank_internal.h
@@ -60,7 +60,8 @@ void WebRtcIsacfix_AllpassFilter2FixDec16C(
    int32_t *filter_state_ch1,
    int32_t *filter_state_ch2);
 
-#if (defined WEBRTC_DETECT_ARM_NEON) || (defined WEBRTC_ARCH_ARM_NEON)
+#if (defined WEBRTC_DETECT_ARM_NEON) || (defined WEBRTC_ARCH_ARM_NEON) || \
+  (defined WEBRTC_ARCH_ARM64_NEON)
 void WebRtcIsacfix_AllpassFilter2FixDec16Neon(
    int16_t *data_ch1,
    int16_t *data_ch2,
diff --git a/webrtc/modules/audio_coding/codecs/isac/fix/source/isacfix.c b/webrtc/modules/audio_coding/codecs/isac/fix/source/isacfix.c
index 922e0299b..50d86389d 100644
--- a/webrtc/modules/audio_coding/codecs/isac/fix/source/isacfix.c
+++ b/webrtc/modules/audio_coding/codecs/isac/fix/source/isacfix.c
@@ -198,14 +198,17 @@ int16_t WebRtcIsacfix_FreeInternal(ISACFIX_MainStruct *ISAC_main_inst)
  * This function initializes function pointers for ARM Neon platform.
  */
 
-#if (defined WEBRTC_DETECT_ARM_NEON || defined WEBRTC_ARCH_ARM_NEON)
+#if (defined WEBRTC_DETECT_ARM_NEON || defined WEBRTC_ARCH_ARM_NEON) || \
+  (defined WEBRTC_ARCH_ARM64_NEON)
 static void WebRtcIsacfix_InitNeon(void) {
   WebRtcIsacfix_AutocorrFix = WebRtcIsacfix_AutocorrNeon;
   WebRtcIsacfix_FilterMaLoopFix = WebRtcIsacfix_FilterMaLoopNeon;
   WebRtcIsacfix_Spec2Time = WebRtcIsacfix_Spec2TimeNeon;
   WebRtcIsacfix_Time2Spec = WebRtcIsacfix_Time2SpecNeon;
+#if !(defined WEBRTC_ARCH_ARM64_NEON)
   WebRtcIsacfix_CalculateResidualEnergy =
       WebRtcIsacfix_CalculateResidualEnergyNeon;
+#endif
   WebRtcIsacfix_AllpassFilter2FixDec16 =
       WebRtcIsacfix_AllpassFilter2FixDec16Neon;
   WebRtcIsacfix_MatrixProduct1 = WebRtcIsacfix_MatrixProduct1Neon;
@@ -334,7 +337,7 @@ int16_t WebRtcIsacfix_EncoderInit(ISACFIX_MainStruct *ISAC_main_inst,
   if ((WebRtc_GetCPUFeaturesARM() & kCPUFeatureNEON) != 0) {
     WebRtcIsacfix_InitNeon();
   }
-#elif defined(WEBRTC_ARCH_ARM_NEON)
+#elif defined(WEBRTC_ARCH_ARM_NEON) || defined(WEBRTC_ARCH_ARM64_NEON)
   WebRtcIsacfix_InitNeon();
 #endif
 
diff --git a/webrtc/modules/audio_coding/codecs/isac/isacfix.gypi b/webrtc/modules/audio_coding/codecs/isac/isacfix.gypi
index a6a7f9777..9957dfde5 100644
--- a/webrtc/modules/audio_coding/codecs/isac/isacfix.gypi
+++ b/webrtc/modules/audio_coding/codecs/isac/isacfix.gypi
@@ -95,6 +95,9 @@
             }],
           ],
         }],
+        ['target_arch=="arm64"', {
+          'dependencies': ['isac_neon', ],
+        }],
         ['target_arch=="mipsel" and mips_arch_variant!="r6" and android_webview_build==0', {
           'sources': [
             'fix/source/entropy_coding_mips.c',
@@ -128,7 +131,7 @@
     },
   ],
   'conditions': [
-    ['target_arch=="arm" and arm_version>=7', {
+    ['target_arch=="arm" and arm_version>=7 or target_arch=="arm64"', {
       'targets': [
         {
           'target_name': 'isac_neon',
@@ -156,6 +159,21 @@
                 '-ffat-lto-objects',
               ],
             }],
+            ['target_arch=="arm64"', {
+              'sources!': [
+                'fix/source/filterbanks_neon.S',
+                'fix/source/filters_neon.S',
+                'fix/source/lattice_neon.S',
+                'fix/source/lpc_masking_model_neon.S',
+                'fix/source/transform_neon.S',
+              ],
+              'sources': [
+                'fix/source/filterbanks_neon.c',
+                'fix/source/filters_neon.c',
+                'fix/source/lattice_neon.c',
+                'fix/source/transform_neon.c',
+              ],
+            }]
           ],
         },
       ],