diff --git a/modules/python/CMakeLists.txt b/modules/python/CMakeLists.txt
index 461ebca03..81cf81df8 100644
--- a/modules/python/CMakeLists.txt
+++ b/modules/python/CMakeLists.txt
@@ -60,7 +60,7 @@ add_custom_command(
    DEPENDS ${opencv_hdrs})
 
 add_library(${the_module} SHARED src2/cv2.cpp ${CMAKE_CURRENT_BINARY_DIR}/generated0.i ${cv2_generated_hdrs} src2/cv2.cv.hpp)
-if(PYTHON_DEBUG_LIBRARIES)
+if(PYTHON_DEBUG_LIBRARIES AND NOT PYTHON_LIBRARIES MATCHES "optimized.*debug")
   target_link_libraries(${the_module} debug ${PYTHON_DEBUG_LIBRARIES} optimized ${PYTHON_LIBRARIES})
 else()
   target_link_libraries(${the_module} ${PYTHON_LIBRARIES})